Cell Physiology in Health and Disease

The molecular processes taking place inside cells underlie life itself. Understanding these cellular activities enables us to appreciate the normal functions of living cells, to explain the molecular basis of diseases and inspires the development of new treatments. This course deals with the basic physiology of cells and the origins of disease, with a particular emphasis on membrane transport processes. The proteins that control entry and exit to the cell provide the fundamental interface between cells and their surroundings, controlling such things as the electrical excitability of nerves, the secretion of hormones and the uptake of drugs. This course will cover the following topics: cell and membrane structure and function; membrane channels and transporters and their roles in nutrient uptake, ion homeostasis, cell signalling and drug resistance; the electrical properties of membranes; the cellular and molecular basis of the excitability of the nervous system; excitation-contraction coupling in muscle; signal transduction; the molecular structure and function of membrane transport proteins; the molecular basis of the action of a number of drugs; diseases involving transporter and channel defects. Specific examples include explaining the molecular origins of epilepsy and designing novel treatments for malaria. Students will comprehend how molecular processes give rise to cellular function, and gain the ability to apply this knowledge to explain the basis of a range of human diseases. The course is designed to provide skills to those wanting to apply their chemical knowledge as well as those anticipating a future career in medical sciences. Students will learn to analyse and synthesise data to produce testable hypotheses that they can communicate to others. Honours Pathway Option (HPO): HPO options available and may vary from year to year. Students should contact the course convener directly for HPO option.